Table 1. Predicted by PASS online biological activity spectrum Topiramate molecule (PubChem CID: 5284627) at the threshold
Pa | Pi | Activity | Known Activities |
0.995 |
0.002 |
Anticonvulsant |
+ |
0.988 |
0.000 |
Carbonic anhydrase II stimulant* |
+ |
0.954 |
0.001 |
Antialcoholic |
+ |
0.925 |
0.001 |
Bipolar disorder treatment |
+ |
0.923 |
0.002 |
CYP2C19 inhibitor |
+ |
0.920 |
0.002 |
CYP3A4 inducer |
+ |
0.914 |
0.002 |
CYP3A inducer |
+ |
0.907 |
0.001 |
Growth stimulant |
|
0.897 |
0.003 |
Ophthalmic drug |
|
0.893 |
0.006 |
CYP3A4 substrate |
+ |
0.882 |
0.003 |
Antineurogenic pain |
+ |
0.874 |
0.007 |
CYP3A substrate |
+ |
0.862 |
0.003 |
Antiglaucomic |
|
0.855 |
0.002 |
Antismoking |
+ |
0.826 |
0.001 |
Carbonic anhydrase V inhibitor |
|
0.810 |
0.001 |
Obsessive-compulsive disorder treatment |
+ |
0.812 |
0.003 |
GABA receptor agonist |
+ |
0.802 |
0.004 |
Antiepileptic |
+ |
0.731 |
0.001 |
Carbonic anhydrase IX inhibitor |
|
0.710 |
0.004 |
Sodium channel blocker |
+ |
0.660 |
0.004 |
Imidazoline I1 receptor agonist |
|
0.597 |
0.004 |
Antimigraine |
+ |
0.589 |
0.001 |
Carbonic anhydrase inhibitor |
|
0.563 |
0.001 |
Carbonic anhydrase II inhibitor* |
+ |
0.564 |
0.003 |
Gastric antisecretory |
+ |
0.546 |
0.016 |
Antiobesity |
+ |
0.489 |
0.030 |
Antiallergic |
|
0.468 |
0.026 |
CYP17 inhibitor |
|
0.445 |
0.009 |
Dependence treatment |
+ |
0.425 |
0.001 |
Carbonic anhydrase I inhibitor |
|
0.463 |
0.048 |
Analgesic |
+ |
0.434 |
0.042 |
Glucan 1,4-alpha-maltotriohydrolase inhibitor |
|
Notes. An asterisk indicates potentially contradictory predictions.