Table 1. Predicted by PASS online biological activity spectrum Topiramate molecule (PubChem CID: 5284627) at the threshold

Pa Pi Activity Known Activities

0.995

0.002

Anticonvulsant

+

0.988

0.000

Carbonic anhydrase II stimulant*

+

0.954

0.001

Antialcoholic

+

0.925

0.001

Bipolar disorder treatment

+

0.923

0.002

CYP2C19 inhibitor

+

0.920

0.002

CYP3A4 inducer

+

0.914

0.002

CYP3A inducer

+

0.907

0.001

Growth stimulant

 

0.897

0.003

Ophthalmic drug

 

0.893

0.006

CYP3A4 substrate

+

0.882

0.003

Antineurogenic pain

+

0.874

0.007

CYP3A substrate

+

0.862

0.003

Antiglaucomic

 

0.855

0.002

Antismoking

+

0.826

0.001

Carbonic anhydrase V inhibitor

 

0.810

0.001

Obsessive-compulsive disorder treatment

+

0.812

0.003

GABA receptor agonist

+

0.802

0.004

Antiepileptic

+

0.731

0.001

Carbonic anhydrase IX inhibitor

 

0.710

0.004

Sodium channel blocker

+

0.660

0.004

Imidazoline I1 receptor agonist

 

0.597

0.004

Antimigraine

+

0.589

0.001

Carbonic anhydrase inhibitor

 

0.563

0.001

Carbonic anhydrase II inhibitor*

+

0.564

0.003

Gastric antisecretory

+

0.546

0.016

Antiobesity

+

0.489

0.030

Antiallergic

 

0.468

0.026

CYP17 inhibitor

 

0.445

0.009

Dependence treatment

+

0.425

0.001

Carbonic anhydrase I inhibitor

 

0.463

0.048

Analgesic

+

0.434

0.042

Glucan 1,4-alpha-maltotriohydrolase inhibitor

 

Notes. An asterisk indicates potentially contradictory predictions.