Dynamics of cytokine level in saliva depending on the presence/absence of regional and distant metastasis

Тable 4. Dynamics of cytokine level in saliva depending on the presence/absence of regional and distant metastasis

Parameter	N₀M₀, n=31	N_1-3M₀, n=22	N_1-3M₁, n=14
IL-2	1.18 [0.64; 2.21]	1.16 [0.70; 2.35]	1.01 [0.60; 2.73]
IL-4	0.88 [0.16; 1.59]	0.69 [0.29; 1.16]	0.69 [0.25; 1.75]
IL-6	0.56 [0.33; 3.93]	1.39 [0.91; 4.00]	1.67 [0.47; 2.34]
IL-8	96.40 [60.30; 242.00]	125.03 [79.40; 214.00]	100.00 [46.30; 231.00]
IL-10	2.09 [0.85; 3.03]	1.79 [1.29; 2.87]	1.93 [1.31; 3.10]
IL-18	8.93 [4.04; 21.70]	13.60 [8.76; 61.80] p=0.0461	33.80 [17.50; 111.00] p=0.0236
CRP	0.016 [0.015; 0.028]	0.057 [0.021; 0165] p=0.0076	0.034 [0.027; 0053] p=0.0486
TNF-α	0.49	1.38 [0.76; 1.90]	0.95 [0.19; 1.71]

Notes. p – statistically significant differences compared to the group N₀M₀