Name

Company

Mechanism of action or target

Reference

AADvac-1

Axon Neuroscience

Tau aggregation

81

AD-02

AFFiRiS

Anti beta-amyloid

49

AD-04

AFFiRiS

Anti beta-amyloid

47, 48

AN2/AVex-73 (Anavex-2-73)

Anavex Life Science

Blocks sodium channels and acts as agonist of Sigma-1 receptors and M1 muscarinic receptors, and AChE inhibitor

117

Atorvastatin (Lipitor)

Pfizer

Lowers cholesterol levels

183, 184

AVN-101

Avineuro

Not disclosed

199

AVN-397

Avineuro

Not disclosed

198

AZD-3480 (Isproniciline)

Targacept

Agonist of alpha-4-beta-2-nAChR

100

BAN-2401

Eisai

Anti beta-amyloid

51

Benfotiamine

Burke Medical Research Institute

Neuroprotector

175

Bexarotene

Eisai

Anti beta-amyloid

176, 177

BI-409306

Boehringer Ingelheim

Phosphodiesterase inhibitor

139

BLU-8499

Alzheon

Anti-amyloidogenic agent

76

Bryostatin 1

Blanchette Rockefeller Neurosciences Institute

Activator of protein kinase C (PKC) isozymes (delta and epsilon)

141

Curcumin

NOW Foods

Antioxidant

163

DAOI-B (Sodium benzoate)

Chang Gung Memorial Hospital

Inhibits D-amino acid oxidases

105

Davunetide (AL-108)

Allon Therapeutics Inc., Paladin Labs Inc.

Glial cell mediator of vasoactive intestinal peptide (VIP)-induced neuroprotection

146, 147

Dexpramipexole

Biogen

Dopamine receptor agonist

118

E-2609

Eisai Co

BACE-1 inhibitor

65

Etanercept (Enbrel)

Amgen, Inc., Pfizer

Inflammation

162

EVP-0962

FORUM Pharm

BACE-1 inhibitor

67

Exenatide

NIH

Agonists of human glucagon-like peptide-1 (amino acids 7-37)

192

Isotretinoin

Hexal AG

Retinoid receptors

179

Ladostigil

Avraham

Inhibitor of acetylcholinesterase and monoamine oxidase A and B

133

Levetiracetam

AgeneBio

N-type calcium channel (Ca(v) 2.2) blocker

120, 121

Liraglutide

Imperial College

Agonists of human glucagon-like peptide-1 (amino acids 7-37)

191

LND-101001

Lupin

Not disclosed

195

Lu-AF-20513

Lundbeck

Antioxidant

161

Methylene Blue

TauRx Therapeutics

Tau aggregation

85

MK-7622

Merck&Co

Not disclosed

196, 197

MSDC-0160

Metabolic Solutions

Antidiabetic

193

Nelonicline (ABT-126)

AbbVie

Nicotinic alpha-7-nAChR agonist

99

Octagam (immunoglobulin IVIG)

Octapharma AG

Anti beta-amyloid

56

ORM-12741

Orion

Alpha 2C-adrenoceptor antagonist

116

Pitavastatin

Kowa

Statin

183

Ponezumab (PN-1219)

Pfizer

Anti beta-amyloid

55

Posiphen

QR Pharma

Antiamyloidogenic agent

71

PQ-912

Probiodrug AG

Inhibitor of glutaminekinase

144

PXT-864

Pharnext

Multitarget: NMDAR and GABA-B antagonist, modulator of metabotropic glutamate receptors

104

Quercetin

Twinlab

Antioxidant

163

Rasagiline

Teva

Monoamine oxidase type B (MAO-B) inhibitor

136

Rilapladib (SB-659032)

GlaxoSmithKline

Inhibitor of phospholipase A2

137

Riluzole

Rockefeller University

Multitarget: group of targets in the glutamatergic system and different types of ion channels

122-124

Ro-63-8695

GlaxoSmithKline

Anti-human serum amyloid P (Anti-SAP), antiamyloidogenic agents

74, 75

RPh-201

Regenera Pharma

Not disclosed

200

S-38093

Servier

Ionic channel modulator, antagonist of H3-histamine receptors (H3R)

113

S-47445 (CX-1632)

RespireRx Pharmaceuticals

Ionotropic glutamate receptor

106, 107

Sargramostim (Leukine)

Perrigo

Granulocyte-macrophage-stimulating agent

154, 155

Simvastatin

NIA

Statin

185, 186

SUVN-502

Suven Life Sciences

5-HT6 receptor antagonist

93

T-817MA

Toyama, FUJIFILM

Neurotrophic agent

145

Tamibarotene

Osaka City University

Retinoic acid receptor (RAR) alpha agonist

178

TRx-0014

TauRx Therapeutics

Tau aggregation

86, 87

UB-311

United Biomedical

Anti beta-amyloid

52, 53

UE-2343

Actinogen

Inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1

134

VX-745

EIP Pharma

MAPK p38 Inhibitor

142, 143

Xanamen

Actinogen

Inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1

134