/IC50CaE
/IC50CaE
Ia
6.14 ± 0.73
3220 ± 408
8420 ± 720
524
1371
Ib
7.41 ± 0.54
7320 ± 270
8340 ± 420
988
1126
Ic
13.10 ± 1.28
4620 ± 180
70430 ± 5310
353
5376
Id
4.95 ± 0.60
759 ± 74
8060 ± 270
153
1628
Table 1. Inhibitor activity (IC50, nM) and selectivity of Foxins (alkyl-2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates) I against CaE, AChE and BChE.
| Compounds | IC50 (нM), n=3 | Selectivity | |||
| CaE | AChE | BChE |
IC50AChE /IC50CaE |
IC50BChE /IC50CaE |
|
|
Ia |
6.14 ± 0.73 |
3220 ± 408 |
8420 ± 720 |
524 |
1371 |
|
Ib |
7.41 ± 0.54 |
7320 ± 270 |
8340 ± 420 |
988 |
1126 |
|
Ic |
13.10 ± 1.28 |
4620 ± 180 |
70430 ± 5310 |
353 |
5376 |
|
Id |
4.95 ± 0.60 |
759 ± 74 |
8060 ± 270 |
153 |
1628 |