Table 2. Esterase profile of some 7-hydroxy-7-polyfluoroalkyl-4,7-dihydroazolo [5,1-c] [1,2,4] triazines II.

Compounds

Inhibitor activity of compounds
(IC50 (μM) ± SEM or % inhibition of the enzyme at 20 μM compound)

CaE

AChE

BChE

IIa

3.91±0.43

13.6±1.22 %

22.0±2.4 %

IIb

0.46±0.04

n.a.

16.2±1.7 %

IIc

0.96±0.08

11.7±1.2 %

11.6±1.3 %

IId

3.6±0.5

n.a.

n.a.

IIe

0.98±0.08

n.a.

3.7±0.5 %

IIf

0.83±0.07

n.a.

n.a.

Note. n.а. – not active