e00027 Table 1.

Table 1. Inhibitor activity and selectivity of conjugates 4a (n=1), 4b (n=2), 5a (n=1), 5b (n=2) toward AChE, BChE and CaE.

Compound	IC₅₀±SEM (µM), n=3			Selectivity
	IC₅₀±SEM (µM), n=3			IC₅₀ AChE / IC₅₀ BChE	IC₅₀ CaE / IC₅₀ BChE
	AChE	BChE	CaE	IC₅₀ AChE / IC₅₀ BChE	IC₅₀ CaE / IC₅₀ BChE
4a	6.27 ± 0.12	0.835 ± 0.066	84.0 ± 6.7	7.5	100
4b	2.29±0.18	0.10±0.01	2.82 ± 0.25	22.9	28.2
5a	2.47 ± 0.07	0.0069 ± 0.0006	>100	360.0	>14500
5b	0.36 ± 0.03	0.0064 ± 0.0006	33.9 ± 3.1	56.8	5300
Tacrine	0.60 ± 0.05	0.0295 ± 0.0002	>100	20.3	>3400
BNPP	n.a.	n.a.	1.80 ± 0.11	-*	-

Note: n.a. - not active; * - not determined