Table 1. In vitro inhibitor activity (ki , M-1min-1) of dialkylphosphates diEt-PFP, diBu-PFP and diPr-DClVP against individual enzymes AChE, NTE, BChE, CaE (esterase profile of OPCs).
|
k i , M-1мин-1 |
||||
|
Compound |
AChE |
NTE |
BChE |
CaE |
|
diEt-PFP |
(1.80 ± 0.11) × 103 |
(1.31 ± 0.08) × 102 |
(4.50 ± 0.19) × 103 |
(1.02 ± 0.04) × 105 |
|
diBu-PFP |
(8.44 ± 0.34) × 104 |
(5.6 ± 0.18) × 105 |
(2.47 ± 0.43) × 106 |
(1.09 ± 0.08) × 107 |
|
diPr-DClVP |
(5.97 ± 0.12) × 105 |
(2.10 ± 0.16) × 106 |
(1.03 ± 0.11) × 107 |
(4.7 ± 0.21) × 107 |