e00028 Table 2.

Table 2. Inhibitor selectivity of diEt-PFP, diBu-PFP and diPr-DClVP to individual enzymes AChE, NTE, BChE, CaE and acute toxicity of OPC.

Selectivity = ratio of corresponding k_i values:
S(EOH_X/EOH_Y) = k_i(EOH_X) / k _i(EOH_Y)*

LD₅₀, mg/kg

Compound

BChE/AChE

CaE/AChE

BChE/NTE

CaE/NTE

NTE/AChE =
RIP

diEt-PFP

2.5

56.6

34.6

778.6

0.07

200 (161 ÷ 239)

diBu-PFP

29.3

129

4.4

19.5

6.6

>2000

diPr-DClVP

17.3

78.7

4.9

23.5

3.5

15 (13.4 ÷ 17.3)

Note: * - Х,Y = AChE, NTE, BChE, CaE

Selectivity = ratio of corresponding k_i values: S(EOH_X/EOH_Y) = k_i(EOH_X) / k _i(EOH_Y)*						LD₅₀, mg/kg
Compound	BChE/AChE	CaE/AChE	BChE/NTE	CaE/NTE	NTE/AChE = RIP	LD₅₀, mg/kg
diEt-PFP	2.5	56.6	34.6	778.6	0.07	200 (161 ÷ 239)
diBu-PFP	29.3	129	4.4	19.5	6.6	>2000
diPr-DClVP	17.3	78.7	4.9	23.5	3.5	15 (13.4 ÷ 17.3)