e00028 Table 3.

Table 3. Median effective doses (ED₅₀, mg/kg) for diEt-PFP, diBu-PFP and diPr-DClVP as esterases inhibitors in mouse blood 1h after i.p. compounds administration.

OPC

ED₅₀, mg/kg

ED₅₀(NTE)/
ED₅₀(AChE)

AChE

NTE

BChE

CaE

diEt-PFP

>300*

no inhibition
at dose
200 mg/kg

46.8 ± 1.5

25.0 ± 1.0

0

diBu-PFP

154 ± 5

36.3 ± 3.6

25.1 ± 3.6

3.1 ± 0.3

4.24

diPr-DClVP

4.0 ± 0.2

2.0 ± 0.1

1.58 ± 0.11

< 0.2 **

2.0

Note: * - 30% inhibition at dose 200 mg/kg; ** - 70% inhibition at dose 0.3 mg/kg

OPC	ED₅₀, mg/kg				ED₅₀(NTE)/ ED₅₀(AChE)
OPC	AChE	NTE	BChE	CaE	ED₅₀(NTE)/ ED₅₀(AChE)
diEt-PFP	>300*	no inhibition at dose 200 mg/kg	46.8 ± 1.5	25.0 ± 1.0	0
diBu-PFP	154 ± 5	36.3 ± 3.6	25.1 ± 3.6	3.1 ± 0.3	4.24
diPr-DClVP	4.0 ± 0.2	2.0 ± 0.1	1.58 ± 0.11	< 0.2 **	2.0