Table 2. The dosage form of OSPL-502 pharmacokinetic parameters after oral administration of the dosage form (i/p), calculated as a substance, a dose of 10 mg/kg and after intravenous administration (i/v) of 2 mg/kg of OSPL-502 compound to CD rats.
|
Parameter |
Dosage, mg/kg |
|
|
10, i/p |
2, i/v |
|
|
The area under the concentration-time curve 0-48, ng*h/ml |
2438,1 |
962,6 |
|
The rate of elimination (Кel), h -1 |
0,00941 |
0,01794 |
|
Half-elimination period (T1/2), min |
73,641 |
38,624 |
|
The time to reach the maximum concentration (Т max), h |
1,5 |
0,25 |
|
The maximum concentration (Сmax), ng/ml |
2451,71 |
2740,22 |
|
Volume of distribution (Vd), ml/kg |
4359,197 |
2247,191 |
|
Total clearance (Clt), ml/min*kg |
41,023 |
40,319 |