Таблица 1. Структуры ацетилхолиновых мускариновых рецепторов, представленные в PDB.

Receptor

M1

M2

M3

M4

M5

PDB

5CXV

3UON, 4MQS,
4MQT

4DAJ, 4U14,
4U15, 4U16

5DSG

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Organism

H.sapiens

H.sapiens

R.norvegicus

H.sapiens

 

Insert part/
proper part/
total

160/291/451

160/278/438

118/273/391

185/207/392

 

Identity with M1 (%)

100

52

58.6

53.4

60.8

Identity with M2 (%)

52

100

48.4

62.4

48.9

Identity with M3 (%)

58.6

48.4

100

47.6

52.8

Identity with M4 (%)

53.4

62.4

47.6

100

49.6

Identity with M5 (%)

60.8

48.9

52.8

49.6

100

Ligand with crystal

Tiotropium

Iperoxo;
(3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate

Tiotropium;
N-methyl scopolamine

Tiotropium