Table 1. e00074

Table 1. Binding energy for the bioactive constituents at the active site versus allosteric binding pocket of PTP1B

Seaweed bioactive component	IC₅₀ (µM)	Binding Energy (kcal/mol)
Seaweed bioactive component	IC₅₀ (µM)	Active site	Allosteric site
Phlorofucofuroeckol-A	0.56^*	-8.0	-8.6
Dieckol	1.18^*	-9.0	-9.2
7-phloroeckol	2.09^*	-8.1	-8.5
Eckol	2.64^*	-7.7	-8.2
Dioxinodehydroeckol	29.97^*	-8.6	-7.9
Phloroglucinol	55.48^*	-2.1	-4.8
Inhibitor 3 (Reference)	8.0^**	-9.0	-8.8

Note. *Data from Moon et al, 2004 [23], **Data from Wiesmann et al., 2004 [7].