Table 1. Top 20 up-regulated and down-regulated proteins in anembryonic chorionic villus sampling identified from LC-MS/MS.
Accession |
Description |
Gene symbol |
Peptides* |
Score |
MW (kDa) |
Fold change |
Chromosome |
|
Up-regulated |
||||||||
1 |
PGS2_HUMAN |
Decorin |
DCN |
4 (3) |
91.21 |
39.7 |
12.6 |
12 |
2 |
CP51A_HUMAN |
Lanosterol 14-alpha demethylase |
CYP51A1 |
6 (2) |
110.62 |
56.8 |
2.93 |
7 |
3 |
MVP_HUMAN |
Major vault protein |
MVP |
8 (5) |
130.78 |
99.3 |
35.61 |
16 |
4 |
CSH_HUMAN |
Chorionic somatomammotropin hormone |
CSH1 |
3 (2) |
179.94 |
25.0 |
12.85 |
17 |
5 |
CNDP2_HUMAN |
Cytosolic non-specific dipeptidase |
CNDP2 |
24 (18) |
1149.77 |
52.9 |
3.17 |
18 |
6 |
YES_HUMAN |
Tyrosine-protein kinase Yes |
YES1 |
2 (1) |
76.47 |
60.8 |
1.46 |
18 |
7 |
ATPA_HUMAN |
ATP synthase subunit alpha, mitochondrial |
ATP5A1 |
36 (29) |
2174.84 |
59.8 |
2.76 |
18 |
Down-regulated |
||||||||
8 |
VIME_HUMAN |
Vimentin |
VIM |
71 (46) |
5463.76 |
53.6 |
1.68 |
10 |
9 |
K2C7_HUMAN |
Keratin, type II cytoskeletal 7 |
KRT7 |
7 (1) |
141.28 |
51.4 |
4.72 |
12 |
10 |
EZRI_HUMAN |
Ezrin |
EZR |
6 (4) |
76.05 |
69.4 |
1.78 |
6 |
11 |
PDIA1_HUMAN |
Protein disulfide-isomerase |
P4HB |
13 (12) |
542.78 |
57.1 |
6.58 |
17 |
12 |
G6PI_HUMAN |
Glucose-6-phosphate isomerase |
GPI |
12 (9) |
643.71 |
63.1 |
13.2 |
19 |
13 |
ACON_HUMAN |
Aconitate hydratase, mitochondrial |
AC |
16 (13) |
579.75 |
84.5 |
4.05 |
22 |
14 |
KCRB_HUMAN |
Creatine kinase B-type |
CKB |
18 (12) |
755.75 |
42.6 |
11.86 |
14 |
15 |
G3P_HUMAN |
Glyceraldehyde-3-phosphate dehydrogenase |
GAPDH |
3 (2) |
64.23 |
36.1 |
1.96 |
12 |
16 |
PGK1_HUMAN |
Phosphoglycerate kinase 1 |
PGK1 |
34 (20) |
2123.13 |
44.6 |
15.2 |
X |
17 |
ENOA_HUMAN |
Alpha-enolase |
EN01 |
38 (28) |
2545.94 |
47.1 |
11.38 |
1 |
18 |
1433Z_HUMAN |
14-3-3 protein zeta/delta |
YWHAZ |
3 (1) |
31.44 |
27.7 |
1.65 |
8 |
19 |
LMAN1_HUMAN |
Protein ERGIC-53 |
LMAN1 |
7 (6) |
201.73 |
57.5 |
4.47 |
18 |
20 |
THIM_HUMAN |
3-ketoacyl-CoA thiolase, mitochondrial |
ACAA2 |
14 (13) |
619.77 |
41.9 |
7.9 |
18 |
Note.* – the amount of peptides used for protein identification; the number of highly specific peptides, i.e peptides automatically selected for identification and quantification by Progenesis LC-MS software, is given in brackets.