Table 1. Top 20 up-regulated and down-regulated proteins in anembryonic chorionic villus sampling identified from LC-MS/MS.

 

Accession

Description

Gene symbol

Peptides*

Score

MW (kDa)

Fold change

Chromosome

Up-regulated

1

PGS2_HUMAN

Decorin

DCN

4 (3)

91.21

39.7

12.6

12

2

CP51A_HUMAN

Lanosterol 14-alpha demethylase

CYP51A1

6 (2)

110.62

56.8

2.93

7

3

MVP_HUMAN

Major vault protein

MVP

8 (5)

130.78

99.3

35.61

16

4

CSH_HUMAN

Chorionic somatomammotropin hormone

CSH1

3 (2)

179.94

25.0

12.85

17

5

CNDP2_HUMAN

Cytosolic non-specific dipeptidase

CNDP2

24 (18)

1149.77

52.9

3.17

18

6

YES_HUMAN

Tyrosine-protein kinase Yes

YES1

2 (1)

76.47

60.8

1.46

18

7

ATPA_HUMAN

ATP synthase subunit alpha, mitochondrial

ATP5A1

36 (29)

2174.84

59.8

2.76

18

Down-regulated

8

VIME_HUMAN

Vimentin

VIM

71 (46)

5463.76

53.6

1.68

10

9

K2C7_HUMAN

Keratin, type II cytoskeletal 7

KRT7

7 (1)

141.28

51.4

4.72

12

10

EZRI_HUMAN

Ezrin

EZR

6 (4)

76.05

69.4

1.78

6

11

PDIA1_HUMAN

Protein disulfide-isomerase

P4HB

13 (12)

542.78

57.1

6.58

17

12

G6PI_HUMAN

Glucose-6-phosphate isomerase

GPI

12 (9)

643.71

63.1

13.2

19

13

ACON_HUMAN

Aconitate hydratase, mitochondrial

AC

16 (13)

579.75

84.5

4.05

22

14

KCRB_HUMAN

Creatine kinase B-type

CKB

18 (12)

755.75

42.6

11.86

14

15

G3P_HUMAN

Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

3 (2)

64.23

36.1

1.96

12

16

PGK1_HUMAN

Phosphoglycerate kinase 1

PGK1

34 (20)

2123.13

44.6

15.2

X

17

ENOA_HUMAN

Alpha-enolase

EN01

38 (28)

2545.94

47.1

11.38

1

18

1433Z_HUMAN

14-3-3 protein zeta/delta

YWHAZ

3 (1)

31.44

27.7

1.65

8

19

LMAN1_HUMAN

Protein ERGIC-53

LMAN1

7 (6)

201.73

57.5

4.47

18

20

THIM_HUMAN

3-ketoacyl-CoA thiolase, mitochondrial

ACAA2

14 (13)

619.77

41.9

7.9

18

Note.* – the amount of peptides used for protein identification; the number of highly specific peptides, i.e peptides automatically selected for identification and quantification by Progenesis LC-MS software, is given in brackets.