Table 1. Pharmacokinetic parameters of noopept, dilept and their active metabolites (CPG and M-1) and compound GB-115 in rats after a single oral administration of drug substances.
|
Parameters, units of measurement |
Noopept |
CPG |
Dilept |
Metabolite М-1 |
Compound GB-115 |
|
Cmax, ng/ml |
820.0±37.8 |
725±53.50 |
8.5±0.67 |
506.6±35.46 |
240±19.2 |
|
Tmax, h |
0.17±0.045 |
0.45±0.05 |
0.25±0.09 |
0.33±0.03 |
0.25±0.03 |
|
AUC0→t, ng/ml×h |
200±17.56 |
3445±230.5 |
2.5±0.18 |
1047.32±83.55 |
92.78±8.8 |
|
T1/2, h |
0.12±0.015 |
3.96±0.26 |
0.45±0.12 |
2.09±0.15 |
0.33±0.028 |
|
MRT, h |
0.42±0.03 |
5.89±0.46 |
0.7±0.09 |
1.37±0.028 |
5.08±0.36 |
Note. Cmax, ng/ml – the peak plasma concentration of a drug after administration, Tmax, h – time to reach Cmax, AUC0→t, ng/ml×h – area under the curve, T1/2, h – elimination half-life – the time required for the concentration of the drug to reach half of its original value, MRT, h – the mean residence time of drugs and their metabolites