Table 2. Pharmacokinetic parameters of noopept, dilept and their active metabolite M-1 and compound GB-115 in rabbits after a single oral administration of drug substances.
|
Parameters, units of measurement |
Noopept |
Dilept |
Metabolite М-1 |
Compound GB-115 |
|
Cmax, ng/ml |
1070± 74.90 |
3.10±1.21 |
4.41±1.91 |
191.50±39.16 |
|
Tmax, h |
0.25±0.03 |
0.79±0.10 |
0.69±0.30 |
0.71±0.10 |
|
AUC0→∞, ng/ml×h |
700±63.0 |
4.96±1.91 |
7.31±2.22 |
447.59±165 |
|
T1/2, h |
0.25±0.03 |
1.13±0.12 |
1.18±0.49 |
1.32±0.30 |
|
MRT, h |
0.63±0.05 |
1.50±0.13 |
2.00±0.68 |
1.65±0.38 |
Note. Cmax, ng/ml – the peak plasma concentration of a drug after administration, Tmax, h – time to reach Cmax, AUC0→t, ng/ml×h – area under the curve, T1/2, h – elimination half-life – the time required for the concentration of the drug to reach half of its original value, MRT, h – the mean residence time of drugs and their metabolites