Таблица 1. Влияние тритерпеноидов на репликацию коронавирусов по отношению к клеточным культурам
Compound ID |
EC50 μM |
CC50 μM |
References |
1 |
370 |
not tested |
[18,24] |
1 |
365 ± 12 |
>24000 |
[29] |
2 |
not observed |
20 ± 5 |
[29] |
3 |
5 ± 3 |
15 ± 3 |
[29] |
4 |
40 ± 13 |
>3000 |
[29] |
5 |
35 ± 7 |
1462 ± 50 |
[29] |
6 |
139 ± 20 |
215 ± 18 |
[29] |
7 |
8 ± 2 |
44 ± 6 |
[29] |
8 |
50 ± 10 |
250 ± 19 |
[29] |
9 |
16 ± 1 |
66 ± 8 |
[29] |
10 |
10 |
not tested |
[31] |
Saponans |
20 |
not tested |
[31] |
11 |
1.7 ± 0.1 |
383.2 ± 0.2 |
[7] |
Saikosaponin A |
8.6 ± 0.3 |
228.1 ± 3.8 |
[7] |
Saikosaponin C |
19.9 ± 0.1 |
121.5 ± 0.1 |
[7] |
Saikosaponin D |
13.2 ± 0.3 |
176.2 ± 0.2 |
[7] |
15 |
0.36 |
112 |
[36] |
19 |
0.06 ± 0.02 |
0.81 ± 0.07 |
[43,44] |
20 |
0.91 ± 0.07 |
7.23 ± 0.87 |
[43,44] |
21 |
0.28 ± 0.09 |
12.47 ± 0.97 |
[43,44] |
22 |
0.28 ± 0.11 |
9.32 ± 1.19 |
[43,44] |
23 |
2.90 ± 0.25 |
27.29 ± 5.63 |
[43,44] |
24 |
0.93 ± 0.22 |
13.72 ± 1.35 |
[43,44] |