Table 1. Strucrures of acetylcholine muscarinic receptors available in PDB [4].
|
Receptor |
M1 |
M2 |
M3 |
M4 |
M5 |
|
PDB |
5CXV |
3UON, 4MQS, 4MQT |
4DAJ, 4U14, 4U15, 4U16 |
5DSG |
6OL9 |
|
Species |
H.sapiens |
H.sapiens |
R.norvegicus |
H.sapiens |
H.sapiens |
|
Insert part/ |
160/291/451 |
160/278/438 |
118/273/391 |
185/207/392 |
|
|
Sequence identity with M1(%) |
100 |
52 |
58.6 |
53.4 |
60.8 |
|
Sequence identity with M2(%) |
52 |
100 |
48.4 |
62.4 |
48.9 |
|
Sequence identity with M3(%) |
58.6 |
48.4 |
100 |
47.6 |
52.8 |
|
Sequence identity with M4 (%) |
53.4 |
62.4 |
47.6 |
100 |
49.6 |
|
Sequence identity with M5 (%) |
60.8 |
48.9 |
52.8 |
49.6 |
100 |
|
Ligand with crystal |
Tiotropium |
(3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate |
Tiotropium |
Tiotropium |
Tiotropium |