Таблица 3. Анализ биохимических параметров слюны, влияющих на общую выживаемость пациентов с раком легкого.
Indicators |
Category |
HR (95% CI) |
p-value |
Overall Survival |
|
Months |
% |
||||
Adenocarcinoma |
|||||
Imidazole compounds, mmol/l |
˂0.311 |
1 |
0.00014 |
29.1 |
33.4 |
>0.311 |
3.14 (1.59–6.09)* |
18.2 |
16.4 |
||
Seromucoids, c.u. |
>0.098 |
1 |
0.02320 |
27.1 |
33.1 |
˂0.098 |
2.34 (1.22–4.43)* |
16.5 |
9.9 |
||
Uric acid, nmol/ml |
>83 |
1 |
0.00633 |
27.1 |
40.1 |
˂83 |
2.27 (1.24–4.12)* |
17.9 |
20.6 |
||
IC + Seromucoids + Uric acid |
Favorable prognosis |
1 |
0.00004 |
36.2 |
48.6 |
Other combinations |
2.92 (1.04-8.10)* |
|
21.3 |
21.8 |
|
Unfavorable prognosis |
7.91 (2.52–24.11)* |
|
14.2 |
7.0 |
|
Lung neuroendocrine tumors |
|||||
Urea, mmol/l |
>8 |
1 |
0.15670 |
22.0 |
33.2 |
˂8 |
1.63 (0.59-4.43) |
11.2 |
21.8 |
||
NO, nmol/ml |
>24 |
1 |
0.08330 |
21.1 |
32.7 |
˂24 |
2.71 (0.90-8.02) |
11.2 |
18.3 |
||
ALP, U/l |
>74 |
1 |
0.00555 |
26.0 |
43.8 |
˂74 |
4.93 (1.55-15.33)* |
9.7 |
- |
||
Urea + NO + ALP |
Favorable prognosis |
1 |
0.01184 |
33.5 |
67.9 |
Other combinations |
1.81 (0.19-16.62) |
13.1 |
19.4 |
||
Unfavorable prognosis |
12.50 (1.09-138.71)* |
6.5 |
- |
||
Prognostic saliva values depending on the type of treatment |
|||||
Radical treatment |
|||||
LDH, U/l |
>1748 |
1 |
0.00968 |
38.5 |
68.2 |
545-1748 |
2.54 (0.83-7.71) |
36.7 |
41.7 |
||
˂545 |
7.20 (2.13-23.70)* |
28.7 |
20.8 |
||
Combined treatment |
|||||
NO, nmol/ml |
>42 |
1 |
0.02797 |
31.1 |
56.9 |
15-42 |
3.97 (1.55-9.94)* |
24.8 |
21.0 |
||
˂15 |
5.64 (1.89-16.46)* |
23.8 |
14.2 |
||
Palliative treatment |
|||||
Imidazole compounds, mmol/l |
˂0.311 |
1 |
0.01114 |
14.8 |
4.8 |
>0.311 |
1.08 (0.22-5.20) |
10.1 |
0.26 |
||
NO, nmol/ml |
˂24 |
1 |
0.10560 |
12.5 |
2.9 |
>24 |
1.32 (0.37-4.67) |
10.7 |
0.53 |
||
IC + NO |
Favorable prognosis |
1 |
0.01827 |
16.6 |
6.8 |
Unfavorable prognosis |
2.73 (1.07-12.92)* |
11.0 |
- |
Note. * - различия статистически значимы, p˂0.05