Table 1. Selected genes of human chromosome 18. First, two genes were annotated as encoding the missing proteins (MPs), while four other genes were attributed to the category of functionally uncharacterized but translated to the protein level with high evidence (uPE1). The neXtProt knowl-edgebase was used to obtain information about the gene status, number of amino acid residues in the sequence of the isoform 1 (the longest one), single amino acid polymorphisms (SAPs) according to the dbSNP and COSMIC datasets, and the known splice forms (Iso1, Iso2, Iso3).

Gene Name

HMSD_

HSBP1L1

ANKRD29

C18orf21

KLHL14

TMEM200C

Protein Name

Serpin-like protein HMSD

Heat shock factor-binding protein

Ankyrin repeat domain-containing protein 29

UPF0711 protein C18orf21

Kelch-like protein 14

Trans-membrane protein 200C

NextProt AC

NX_A8MTL9

NX_C9JCN9

NX_Q8N6D5

NX_Q32NC0

NX_Q9P2G3

NX_A6NKL6

Status

MP

MP

uPE1

uPE1

uPE1

uPE1

# of aa in Iso1

139

75

301

220

628

621

variants

(SAPs)

111

56

231

166

385

648

splice forms

Iso1

Iso1

Iso1, Iso3

Iso1, Iso2

Iso1, Iso2

Iso1

qPCR (cDNA copies per cell)

Liver #1

0.00**

0.88

0.02

0.37

0.02

0.33

Liver #3

0.01

0.47

0.10

0.33

0.03

0.42

Liver #5

0.02

0.59

0.07

0.22

0.01

0.52

HepG2

ND*

1.10

0.02

2.29

116.38

0.08

Illumina HiSeq (FPKM)

Liver #1

ND*

3.50

0.00**

4.5

0.00**

0.00**

Liver #3

ND*

2.50

0.50

3.0

0.00**

1.00

Liver #5

ND*

6.00

0.00**

1.5

0.00**

2.00

HepG2

ND*

6.50

0.00**

17.5

2.50

0.00**

ONT MinION (TPM)

Liver #1

0.21

6.31

0.13

6.20

0.00**

0.04

HepG2

0.00**

6.94

0.00**

16.00

1.11

0.00**

Note.* - No reads observed. ** - Rounded to the second decimal place.