Reaction type

Substrate (xenobiotic)

Reduction

Balsalazine, Clonazepam, Digoxin, Metronidazole, Misonidazole, Neoprontosil, Nitrazepam, Olsalazine, Omeprazole, Prontosil, Sulindac, Sulfasalazine, Sulfinpyrazone, Zonisamide

Hydrolysis

Carbenoxolone, Lactulose, Methotrexate, Morphine glucuronide, Nitroglycerin, Sodium picosulphate, Sennosides, Sorivudine

Functional group removal

Flucytosine, Levodopa, Methamphetamine, Phenacetin, Succinylsulfathiazole

N-oxide cleavage

Nizatidine, Ranitidine

Proteolysis

Calcitonin, Insulin

Denitration

Glyceryl trinitrate, Isosorbide dinitrate

Deconjugation

Indomethacin, Irinotecan

Amine formation/amide hydrolysis

Chloramphenicol

Thiazole ring-opening

Levamisole

Acetylation

5-Aminosalicyclic acid

Isoxazole scission

Risperidone

Other

Azetirelin, Hesperidin, Potassium oxonate,