No.

Accession

Description

Gene

Validated Unique Peptides

# Peptides

MW (kDa)

Fold change control/SDS

Spectrum Counting NSAF

Biological process (disease)

Control

SDS

Control

SDS

Control

SDS

1

P25705

ATP synthase subunit alpha, mitochondrial

(ATPA_HUMAN)

ATP5F1A

4

4

36

31

59.7

1.6

0.201

0.126

mitochondrial ATP synthesis (Leigh syndrome, MELAS syndrome)

2

P36952

Serpin B5

(SPB5_HUMAN)

SERPINB5

10

11

25

23

42.1

1

0.207

0.207

regulation of epithelial cell proliferation

tumor suppressor

3

P05120

Plasminogen activator inhibitor 2 (PAI2_HUMAN)

SERPINB2

14

9

16

11

46.6

1.4

0.140

0.103

wound healing, fibrinolysis, negative regulation of apoptosis

4

Q9UIV8

Serpin B13

(SPB13_HUMAN)

 SERPINB13

nd

13

nd

13

44.2

-

nd

0.129

negative regulation of the apoptotic process of keratinocytes, regulation of keratinocyte differentiation and proteolysis, response to UV

5

P29508

Serpin B3 (SPB3_HUMAN)

SERPINB3

nd

13

nd

1

44.5

-

nd

0.080

the process of positive regulation of the proliferation of the cell population, regulates the activity of endopeptidases (hepatocarcinoma)

6

Q96EE3

Nucleoporin SEH1 (SEH1_HUMAN)

SEH1L

11

7

12

8

39.6

1.9

0.083

0.045

necessary for normal mitotic progression and chromosome segregation

7

O43776

Asparagine--tRNA ligase, cytoplasmic (SYNC_HUMAN)

NARS

8

11

12

15

62.9

0.6

0.047

0.083

aminoacylation of tRNA

8

P18621

60S ribosomal protein L17 (RL17_HUMAN)

RPL17

1

1

8

8

21.4

1.2

0.214

0.186

translation, a structural component of the ribosome

9

P32926

Desmoglein-3 (DSG3_HUMAN)

DSG3

8

4

10

7

107. 5

2

0.016

0.008

cell adhesion, keratinization

10

P48594

Serpin B4 (SPB4_HUMAN)

SERPINB4

2

4

9

12

44.8

1

0.056

0.059

can act as a protease inhibitor, modulating the host's immune response against tumor cells

11

O00194

Ras-related protein Rab-27B (RB27B_HUMAN)

RAB27B

3

4

7

7

24.6

0.6

0.037

0.059

regulation of homeostasis of the late pathway of endocytosis, including endosomal positioning, maturation and secretion

12

Q9Y4W6

AFG3-like protein 2 (AFG32_HUMAN)

AFG3L2

7

4

7

6

88.5

2

0.016

0.008

is required for the maturation of paraplegin (SPG7) after it is cleaved by mitochondria-processing peptidase (MPP) and for the maturation of PINK1

13

P22830

Ferrochelatase, mitochondrial (HEMH_HUMAN)

FECH

7

1

7

5

47.8

10

0.027

0.003

catalyzes the introduction of iron into protoporphyrin IX

14

Q96FV9

THO complex subunit 1 (THOC1_HUMAN)

THOC1

nd

1

nd

2

75.7

-

nd

0.002

participates in the apoptosis pathway, which is characterized by activation of caspase-6, increased expression of BAK1 and BCL2L1, and activation of NF-kappa-B

15

O14950

Myosin regulatory light chain 12B (ML12B_HUMAN)

MYL12B

2

2

6

6

19.8

0.7

0.087

0.120

regulation of muscle and non-muscle cell contraction through phosphorylation, cytokinesis

16

Q96KP4

Cytosolic non-specific dipeptidase (CNDP2_HUMAN)

CNDP2

2

1

8

8

52.8

0.7

0.024

0.036

the process of biosynthesis of glutathione, a functional tumor suppressor in gastric cancer through the activation of mitogen-activated protein kinase

17

Q14126

Desmoglein-2

(DSG2_HUMAN)

DSG2

7

2

10

4

122.2

3.5

0.010

0.003

keratinization, cell adhesion (Autoimmune bullous dermatoses, such as pemphigus vulgaris)

18

O43396

Thioredoxin-like protein 1 (TXNL1_HUMAN)

TXNL1

4

6

5

6

32.2

0.6

0.031

0.048

cellular redox homeostasis

19

Q9P0L0

Vesicle-associated membrane protein-associated protein A (VAPA_HUMAN)

VAPA

1

2

11

7

27.9

2.1

0.172

0.081

biosynthesis of sphingolipids, cell death, regulation of lipid transport and membrane synthesis in the ER

20

P49257

Protein ERGIC-53

(LMAN1_HUMAN)

LMAN1

16

17

19

20

57.5

0.8

0.129

0.155

transport of proteins from the ER to the Golgi apparatus, blood coagulation (combined deficiency of factors coagulation V and VIII)

21

P23368

NAD-dependent malic enzyme, mitochondrial (MAOM_HUMAN)

ME2

2

2

18

16

65.4

0.9

0.060

0.070

malate and pyruvate metabolic process, tricarboxylic acid cycle

22

P19404

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUV2_HUMAN)

NDUFV2

8

6

8

6

27. 4

1.9

0.135

0.073

oxidoreductase is involved in electronic transport and the respiratory chain

23

O75351

Vacuolar protein sorting-associated protein 4B

(VPS4B_HUMAN)

VPS4B

1

4

4

5

49.3

0.1

0.003

0.028

cholesterol transport, is involved in cell proliferation, in the regulation of mitotic spindle assembly at different stages of cell division (skin cancer)

24

Q9UBB5

Methyl-CpG-binding domain protein 2 (MBD2_HUMAN)

MBD2

3

1

4

3

43.2

2

0.022

0.011

a transcriptional repressor and plays a role in gene suppression

25

P62314

Small nuclear ribonucleoprotein Sm D1 (SMD1_HUMAN)

SNRPD1

5

4

5

5

13.3

1.5

0.277

0.181

plays a role in mRNA splicing

26

Q06136

3-ketodihydrosphingosine reductase (KDSR_HUMAN)

KDSR

2

2

8

7

36.2

0.9

0.127

0.138

oxidoreductase involved in the biosynthesis of sphingolipids (erythrokeratoderma, genodermatosis)

27

P00167

Cytochrome b5

(CYB5_HUMAN)

CYB5A

1

1

5

5

15.3

1.1

0.205

0.193

Redox processes, electron transport

28

P54578

Ubiquitin carboxyl-terminal hydrolase 14 (UBP14_HUMAN)

USP14

2

2

3

3

56.0

1

0.005

0.005

serves as a physiological inhibitor of endoplasmic reticulum-associated degradation under stress-free conditions

29

Q9BVV7

Mitochondrial import inner membrane translocase subunit Tim21 (TIM21_HUMAN)

TIMM21

2

1

2

1

28.2

2

0.010

0.005

transport of transit proteins across the inner mitochondrial membrane

30

Q96P63

Serpin B12 (SPB12_HUMAN)

 SERPINB12

3

nd

4

nd

46.3

-

0.009

nd

Protease, trypsin and plasmin inhibitor

31

Q9Y5U9

Immediate early response 3-interacting protein 1 (IR3IP_HUMAN)

IER3IP1

2

nd

2

nd

8.9

-

0.040

nd

participates in the regulation of apoptosis participates in the transport of protein between the endoplasmic reticulum and the Golgi apparatus

32

Q14574

Desmocollin-3 (DSC3_HUMAN)

DSC3

2

nd

4

nd

99.9

-

0.003

nd

cell-cell adhesion process

33

Q96ND0

Protein FAM210A (F210A_HUMAN)

FAM210A

2

nd

2

nd

30.8

-

0.009

nd

nucleoplasm, mitochondria & the Golgi apparatus

34

Q13636

Ras-related protein Rab-31 (RAB31_HUMAN)

RAB31

1

nd

1

nd

21.6

-

0.012

nd

key regulators of intracellular membrane transport

35

Q02413

Desmoglein-1 (DSG1_HUMAN)

DSG1

1

nd

4

nd

113.7

-

0.007

nd

cell-cell adhesion process

36

Q8N4Q0

Prostaglandin reductase 3 (PTGR3_HUMAN)

ZADH2

1

3

4

5

40.1

0.6

0.019

0.030

negative regulation of differentiation of adipocyte cells. peroxisome

37

Q9BY50

Signal peptidase complex catalytic subunit SEC11C (SC11C_HUMAN)

SEC11C

1

nd

2

nd

21.5

-

0.006

nd

removes signal peptides from nascent proteins as they move into the lumen of the endoplasmic reticulum

38

Q08554

Desmocollin-1 (DSC1_HUMAN)

DSC1

1

nd

1

nd

99.9

-

0.002

nd

cell-cell adhesion process keratinization