Figure 4. Designed pharmacophore models. a - pharmacophore 1 (used compounds 1/-6), b - pharmacophore 2 (used compounds 7-11), c - pharmacophore 3 (used compounds 12-14), d - pharmacophore 4 (used compounds 15–18). Purple spheres are aromatic fragments, gray spheres are H-bond donor, yellow spheres are H-bond acceptors, green spheres are hydrophobic fragments.