Table 1. Sequences of designed knottins. Modifications in KITs in comparison to MCOTI-II are in Italic

Name

Sequences

MCOTI-II

SGSDGGVCPKILKKCRRDSDCPGACICRGNGYCG

KIT-1

-  -  - DGGLCYLELKKCRRDSDCEGICICRGNGYCG

KIT-2

-  -  - DGVLCYLELKKCRRDSDCEGICICRGNGYCG

KIT-3

-  -  - DGVKCYLELKKCRRDSDCEGICICRGNGYCG

KIT-4

-  -  - DGVTCYLELKKCRRDSDCEGICICRGNGYCG

KIT-5

-  -  -  - GGLCYLELKKCRRDSDCEGICICRGNGYCG

KIT-2_D-Leu12

-  -  - DGVLCYLELKKCRRDSDCEGICICRGNGYCG

KIT-2_D-Lys13

-  -  - DGVLCYLELKKCRRDSDCEGICICRGNGYCG

KIT-2_D-Lys14

-  -  - DGVLCYLELKKCRRDSDCEGICICRGNGYCG