Table 2. The effect of the dosage forms (DF) of rhGM-CSF conjugate and rhGM-CSF on the bone marrow cellularity of CBA mice exposed to cyclophosphamide (CF) (5 days post cytostatic administration)
Animal group |
Total karyocyte count, 106/femur after the administration of |
|
rhGM-CSF conjugate |
rhGM-CSF |
|
Intact |
13.76±1.31 |
|
CF + saline solution |
3.38±0.92 |
4.62±0.81 |
CF + substance |
4.84±0.67 |
5.52±0.85 |
CF +DF |
6.88±0.64* |
3.39±0.63 |
Note.* - the differences are statistically significant compared with the parameters of mice administered with CF and the saline solution, p≤0.0170