Table 2. The effect of the dosage forms (DF) of rhGM-CSF conjugate and rhGM-CSF on the bone marrow cellularity of CBA mice exposed to cyclophosphamide (CF) (5 days post cytostatic administration)

Animal group

Total karyocyte count, 106/femur after the administration of

rhGM-CSF conjugate

rhGM-CSF

Intact

13.76±1.31

CF + saline solution

3.38±0.92

4.62±0.81

CF + substance

4.84±0.67

5.52±0.85

CF +DF

6.88±0.64*

3.39±0.63

Note.* - the differences are statistically significant compared with the parameters of mice administered with CF and the saline solution, p≤0.0170