Table 2. Kaplan-Meier survival rates of mice at 120 hours after paracetamol poisoning at a dose of 425 mg/kg using the Kaplan-Meier method.
|
Parameters |
Groups |
|||||||||
|
Intact group |
Control, Paracetamol, 425 mg/kg |
Xymedon, mg/kg |
Xymedon conjugate with L‑ascorbic acid, мг/кг |
|||||||
|
1 |
10 |
100 |
200 |
2.1 |
21 |
210 |
420 |
|||
|
Average survival time, hours |
120 ± 0* |
61.3 ± 17.7 |
65.2 ± 16.7 |
92.8 ± 11.7 |
76 ± 12.3 |
70.5 ± 15.1 |
73.7 ± 14.5 |
96 ± 10.2 |
92.3 ± 12 |
120 ± 0* |
|
Median survival time, hours |
120 |
3 |
24 |
120 |
48 |
30 |
48 |
120 |
120 |
120 |
* – differences with the control group are significant, at p ≤ 0.05.