Peptide, dosage^a

Peptide + adjuvant composition content

Number of animals^b 

Antibody titers^c

with antipeptide antibodies

with antibodies against E2 and E1E2

antipeptide

anti-E2

anti-E1E2

CR4-CR5, 50 µg

PBS

0

0

-

-

-

CR4-CR5, 20 µg

AF in PBS

0

0

-

-

-

CR4-CR5, 5 µg

PSN in PBS

0

0

-

-

-

CR4-CR5, 50 µg

IM in PBS

0

0

-

-

-

CR4-CR5,0.5 µg

IM-CR4-CR5 in PBS

1+3(67%)

1+3(67%)

1:700

1:20

1:25

CR4-CR5,0.2 µg

IM-CR4-CR5 in PBS

0+2(33%)

0+2(33%)

1:250

-

-

CR4-CR5,0.2 µg

IM-CR4-CR5 + PSN in PBS

2+3(83%)

2+2(67%)

1:1500

1:20

1:25

CR4-CR5, 5 µg

Dextran-CR4-CR5 in PBS

0

0

-

-

-

CR5-CR3, 50 µg

PBS

83

2+3(83%)

1:700

1:30

1:65

CR5-CR3, 5 µg

PBS

0

0

-

-

-

CR5-CR3, 20 µg

AF in PBS

6(100%)

0

1:800

-

-

CR5-CR3, 5 µg

PSN in PBS

1+2(50%)

0

1:150

-

-

CR5-CR3, 50 µg

IM in PBS

1+3(67%)

1+3(67%)

1:400

1:40

1:80

CR5-CR3,0.5 µg

IM-CR5-CR3 in PBS

2+3(83%)

2+3(83%)

1:1500

1:100

1:163

CR5-CR3,0.2 µg

IM-CR5-CR3 in PBS

6(100%)

3+2(83%)

1:1000

1:23

1:31

CR5-CR3,0.2 µg

IM-CR5-CR3 + PSN in PBS

2+3(83%)

2+3(83%)

1:2000

1:70

1:100