Table 1. Evaluation of trypsinolysis efficacy using an external standard of recombinant cytochrome P450 BM-3 (CYP102A1) from gram-positive Bacillus Megaterium

Technical replay number

Number of identified BM3 peptides

Sequence coverage of BM3 (%)

Protocol 1

Protocol 2

Protocol 1

Protocol 2

1

83.0 (50.0%)

76.0 (45.8%)

86.9

83.2

2

84.0 (50.6%)

76.0 (45.8%)

87.4

84.3

3

81.0 (48.8%)

76.0 (45.8%)

86.6

83.6

Mean ± Standard Deviation

82.7 ± 1.5

76.0 ± 0.0

87.0 ± 0.4

83.7 ± 0.5