Biomedical Chemistry: Research and Methods 2024, 7(3), e00222

Age-Related Correlations of Telomere Length of Predator Fish Muscle Tissues with Potentially Different Ageing Mechanisms

M.V. Mikhailova, K.V. Zolotarev*, A.N. Mikhailov, V.I. Nakhod, O.E. Voronko,
D.D. Zhdanov, A.I. Archakov

Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia; *e-mail: fireaxe@mail.ru

Keywords: fish aging; pike (Esox lucius); zander (Sander lucioperca); telomere length; muscle tissue physiology

DOI:10.18097/BMCRM00222

The whole version of this paper is available in Russian.

The mechanisms of aging differ and have their own features both mammals, and in different species groups of fish. Telomere length is an indicator of the theoretical number of cell cycles that cells of a particular tissue can go through; therefore, the age-related dynamics of telomere length characterizes changes in the tissue’s ability to regenerate and is necessary to describe the mechanism of tissue aging. In this work, age-related linear regressions of the telomere lengths of muscle tissue of northern pike (Esox lucius) and zander (Sander lucioperca) were empirically obtained for the wide age groups of individuals of both sexes. The identified significant difference in the dependences on their slope values indicates different degrees of decrease in the ability to regenerate muscle tissue with age, which is consistent with the previously discovered physiological characteristics of the muscle tissue of pike. In both fish species studied, telomere length in females decreases with age much more slowly than in males, which is a common feature in the aging mechanisms of most vertebrates.
Figure 1. Telomere lengths (in thousands of nucleotide pairs) as a function of age for pike and zander, irrespective of the sex of the fish.
Figure 2. Dependences of telomere lengths (in thousands of nucleotide pairs) on age for pike and zander separately for males and females. The equations of dependence for males are highlighted in boxes.

FUNDING

The work was performed within the framework of the Program for Basic Research in the Russian Federation for a long-term period (2021-2030) (No. 122030100170-5).

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