Identification of Androgen Deficiency in Infertility and Reduced Ovarian Reserve Based on HPLCMS/MS and IHLA Measurements

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Published: Dec 16, 2022
DOI: https://doi.org/10.18097/BMCRM00182
Keywords:
HPLC-MS; IHLA; androgen deficiency states

Main Article Content

S.V. Kindysheva
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
A.A. Gavisova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
M.A. Shevtsova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
L.T. Tskhovrebova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
D.A. Biryukova
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
N.L. Starodubtseva
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
T.Yu. Ivanec
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
V.E. Frankevich
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia

Abstract

The androgen deficiency and associated states represent is an important problem that affects the quality of women live. The most widely the androgen influence has been studied in the reproductive period in relation to polycystic ovary syndrome; however about laboratory methods to determine the impact of androgen deficiency and its clinical manifestation in the case of young women with a reduced ovarian reserve and with infertility are still actively discussed. Clinical medicine still needs generally approved markers of androgen deficiency states and its lower reference values. In this work we illustrate the perspective of measurements of steroid hormones panel to verify the diagnosis on the basis of high performance liquid chromatography with tandem mass spectrometry and immunochemical methods.

Article Details

How to Cite
Kindysheva, S., Gavisova, A., Shevtsova, M., Tskhovrebova, L., Biryukova, D., Starodubtseva, N., Ivanec, T., & Frankevich, V. (2022). Identification of Androgen Deficiency in Infertility and Reduced Ovarian Reserve Based on HPLCMS/MS and IHLA Measurements. Biomedical Chemistry: Research and Methods, 5(4), e00182. https://doi.org/10.18097/BMCRM00182
Issue
Vol. 5 No. 4 (2022)
Section
EXPERIMENTAL RESEARCH

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