The Effect of New Synthetic Analogs of Semax Peptide Preparation on AMPA-Receptors in Purkinje Neurons of Cerebellar Rats

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Published: Aug 22, 2018
DOI: https://doi.org/10.18097/BMCRM00033
Keywords:
peptide analogues of Semax AMPA receptors Purkinje neurons

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V.V. Grigoriev
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
V.L. Zamoyski
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
E.V. Bovina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
L.A. Andreeva
Institute of Molecular Genetics of the Russian Academy of Sciences, 2, Academician I.G. Kurchatov’s square, Moscow, 123182 Russia
N.F. Myasoedov
Institute of Molecular Genetics of the Russian Academy of Sciences, 2, Academician I.G. Kurchatov’s square, Moscow, 123182 Russia

Abstract

New peptides analogues of Semax can potentiate AMPA receptors induced currents at lower concentrations (10–11–10–8 M) than those of Semax. This ability suggests that they may have cognitive-stimulating properties.

Article Details

How to Cite
Grigoriev, V., Zamoyski, V., Bovina, E., Andreeva, L., & Myasoedov, N. (2018). The Effect of New Synthetic Analogs of Semax Peptide Preparation on AMPA-Receptors in Purkinje Neurons of Cerebellar Rats. Biomedical Chemistry: Research and Methods, 1(3), e00033. https://doi.org/10.18097/BMCRM00033
Issue
Vol. 1 No. 3 (2018)
Section
EXPERIMENTAL RESEARCH

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