Protective Action of the Extract of Blueberry Leaves Against Glutamate Excitotoxicity on Neurons of the Rat Cerebral Cortex

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Published: Aug 7, 2018
DOI: https://doi.org/10.18097/BMCRM00045
Keywords:
extract blueberry cultured neurons glutamate MK-801 excitotoxicity

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N.N. Lermontova
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
L.N. Petrova
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
T.P. Serkova
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
O.V. Novikova
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
I.M. Bravova
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
M.E. Neganova
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
S.G. Klochkov
Institute of Physiologically Active Compounds of RAS, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia

Abstract

The aqueous extract of blueberry leaves inhibits the glutamate-induced Ca2+ influx into the synaptosomes of rat brain neurons and the IC50 value of this process is close to the IC50 for MK-801, a well-known noncompetitive antagonist of glutamate NMDA subtype receptors. The aqueous extract of blueberry leaves protected the cultured neurons of the rat cerebral cortex from the neurotoxic effect of glutamate, and the inhibition intensity depended on the incubation time with the extract.

Article Details

How to Cite
Lermontova, N., Petrova, L., Serkova, T., Novikova, O., Bravova, I., Neganova, M., & Klochkov, S. (2018). Protective Action of the Extract of Blueberry Leaves Against Glutamate Excitotoxicity on Neurons of the Rat Cerebral Cortex. Biomedical Chemistry: Research and Methods, 1(3), e00045. https://doi.org/10.18097/BMCRM00045
Issue
Vol. 1 No. 3 (2018)
Section
EXPERIMENTAL RESEARCH

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