Pharmacokinetic Studies of New Stimulator of Brain Cognitive Functions OSPL-502

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S.A. Pukhov
V.V. Grigoriev
V.I. Kozlovskiy
A.A. Romanova
G.D. Shishko
M.E. Neganova
S.G. Klochkov


The main pharmacokinetic parameters of a new stimulator of cognitive brain functions, OSPL – 502 have been determined: area under the concentration-time curve, elimination rate constant, half-elimination period, time to reach the maximum concentration, maximum concentration, volume distribution, total clearance and bioavailability of the dosage form. The main metabolites of the active substance of the dosage form of the new stimulator of cognitive functions OSPL – 502 have been analyzed. The data obtained predict the effects of the drug in humans relevant for further clinical investigation.

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How to Cite
Pukhov, S., Grigoriev, V., Kozlovskiy, V., Romanova, A., Shishko, G., Neganova, M., & Klochkov, S. (2018). Pharmacokinetic Studies of New Stimulator of Brain Cognitive Functions OSPL-502. Biomedical Chemistry: Research and Methods, 1(3), e00046.


  1. Kukes, V.G. (2009). Clinical pharmacokinetics: theoretical, applied and political aspects: Guide. Moscow, GEOTAR-Media Publishing.
  2. Concheiro, M., Gray, T.R., Shakleya, D.M., Huestis, M.A. (2010). High-throughput simultaneous analysis of buprenorphine, methadone, cocaine, opiates, nicotine, and metabolites in oral fluid by liquid chromatography tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 398(2), 915-24. DOI
  3. Borgia – pharmacokinetic parameters calculator. Retrieved August 22, 2018 from
  4. Prasolov, I., Dikunets, M., Sukhanova, I., Sobolevsky, T., Rodchenkov, G. (2012). Study on an in vitro metabolism of novel doping substances to facilitate their detection in human urine. Analitika, 6, 6-14.