Pharmacokinetic Studies of New Stimulator of Brain Cognitive Functions OSPL-502

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Published: Aug 22, 2018
DOI: https://doi.org/10.18097/BMCRM00046
Keywords:
pharmacokinetics nootropic HPLC/MS metabolites

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S.A. Pukhov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
V.V. Grigoriev
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
V.I. Kozlovskiy
Branch of Talrose Institute for Energy Problems of Chemical Physics of the Russian Academy of Sciences, 1-10 Acad. Semenov prosp., Chernogolovka, 142432 Russia
A.A. Romanova
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
G.D. Shishko
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
M.E. Neganova
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
S.G. Klochkov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia

Abstract

The main pharmacokinetic parameters of a new stimulator of cognitive brain functions, OSPL – 502 have been determined: area under the concentration-time curve, elimination rate constant, half-elimination period, time to reach the maximum concentration, maximum concentration, volume distribution, total clearance and bioavailability of the dosage form. The main metabolites of the active substance of the dosage form of the new stimulator of cognitive functions OSPL – 502 have been analyzed. The data obtained predict the effects of the drug in humans relevant for further clinical investigation.

Article Details

How to Cite
Pukhov, S., Grigoriev, V., Kozlovskiy, V., Romanova, A., Shishko, G., Neganova, M., & Klochkov, S. (2018). Pharmacokinetic Studies of New Stimulator of Brain Cognitive Functions OSPL-502. Biomedical Chemistry: Research and Methods, 1(3), e00046. https://doi.org/10.18097/BMCRM00046
Issue
Vol. 1 No. 3 (2018)
Section
EXPERIMENTAL RESEARCH

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