Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells

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E.S. Dubrovskaya
A.V. Semakov
S.V. Afanasyeva
M.E. Neganova
V.I. Kozlovski
S.G. Klochkov


An the present study we evaluated the effect of natural sesquiterpene lactones of plants of the genus Inula on the cells of neuroblastoma SK-N-MC under conditions of toxic stress induced by H2O2 and glutamate. Lactones increased cell survival under these conditions and the leader compounds were identified in this series. A putative mechanism for the protective action of lactones on cells under condition toxic stress has been proposed.

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How to Cite
Dubrovskaya, E., Semakov, A., Afanasyeva, S., Neganova, M., Kozlovski, V., & Klochkov, S. (2018). Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells. Biomedical Chemistry: Research and Methods, 1(3), e00051.


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