Biomedical Chemistry: Research and Methods 2020, 3(2), e00127

Аnticoronaviral activity of triterpenoids

M.S. Denisov*, Ya.A. Beloglazova

Institute of Technical Chemistry of the Ural Branch of the RAS,
3 Academician Korolev str., Perm, 614013 Russia; *е-mail:

Keywords:triterpenoids; coronavirus; SARS; MERS; COVID-19


The whole version of this paper is available in Russian.

The discovery and investigations of new therapeutic agents with anticoronaviral activity is extremely important due to the COVID-19 pandemic caused by SARS-CoV-2 virus. Currently, there is no drug against COVID-19, which efficacy has been proved in correspondence with criteria of evidence-based medicine. However, there were some precursors of SARS-CoV-2 belonging to the family Coronaviridae called SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) vuruses. Consequently, a wide range of organic substances of synthetic and natural origin were studied for the anticoronaviral activity. The review summarizes and systematizes the literature data on the anti-coronavirus activity of triterpenoids. The structural features of triterpenoids are discussed, which are important for the mechanisms of anticoronaviral activity. The structures of the most active compounds are presented. The material is classified by approaches to the study of anticoronaviral activity of individual substances or plants extracts. Recommendations for the further research of triterpenoids anticoronaviral activity are given.

Figure 1. The chemical structures of triterpenoids with tested anticoronavirus activity (compounds 1-13).
Figure 2. The chemical structures of triterpenoids with tested anticoronavirus activity (compounds 14-24, 27-31).
Figure 3. The reaction of obtaining of triterpenoid 26 from compound 25 using palladium catalysts.

Table 1. Effects triterpenoids on coronaviruses replication at cell cultures.

Table 2. Quantitative parameters of triterpenoids inhibiting the enzymatic activity of SARS-CoV 3CL protease.


The work was performed by the state order (project no. AAAA-A18-118030790037-7).


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