Pipeline of Mass-spectrometry Data Processing for Diagnostic Molecular Marker Panel Obtaining Using the Example of Search Markers of Breast Cancer Metastasis

Authors

  • A.O. Tokareva Skolkovo Institute of Science and Technology, 30 bld. 1 Bolshoy Boulevard,Moscow, 121205, Russia; V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Center of Chemical Physic, Russian Academy of Sciences, 38 bld. 2 Leninsky avenue, Moscow, 119334 Russia
  • V.V. Chagovets Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
  • A.S. Kononikhin Skolkovo Institute of Science and Technology, 30 bld. 1 Bolshoy Boulevard,Moscow, 121205, Russia; Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
  • N.L. Starodubtseva V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Center of Chemical Physic, Russian Academy of Sciences, 38 bld. 2 Leninsky avenue, Moscow, 119334 Russia; Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
  • V.E. Frankevich Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, 4 bld. 2 Oparina str., Moscow, 117513 Russia
  • E.N. Nikolaev Skolkovo Institute of Science and Technology, 30 bld. 1 Bolshoy Boulevard,Moscow, 121205, Russia

DOI:

https://doi.org/10.18097/BMCRM00156

Keywords:

mass-spectrometry; data processing; biological markers

Abstract

A pathology diagnostic using molecular marker is a perspective direction of clinical medicine. Mass-spectrometry (MS) is a one of methods, which are used for obtaining information about molecular profiles. Selection of species, essential for classification “case/control is an important task for data processing. Pipeline of data processing has been proposed using MS data, obtained during analysis of tumor breast tissue samples and health breast tissue samples, with the aim of metastasis marker selection. As a result, selection of lipid markers that belong to classes, related to metastasis and proliferation processes, makes it possible to create high sensitivity diagnostic model, based on logistic regression. The proposed method is applicable for data processing, obtained by MS analysis of other “omics”: metabolome, proteome, glycome.

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Published

2021-09-30

How to Cite

Tokareva, A., Chagovets, V., Kononikhin, A., Starodubtseva, N., Frankevich, V., & Nikolaev, E. (2021). Pipeline of Mass-spectrometry Data Processing for Diagnostic Molecular Marker Panel Obtaining Using the Example of Search Markers of Breast Cancer Metastasis. Biomedical Chemistry: Research and Methods, 4(3), e00156. https://doi.org/10.18097/BMCRM00156

Issue

Section

EXPERIMENTAL RESEARCH