The Effect of New Synthetic Analogs of Semax Peptide Preparation on AMPA-Receptors in Purkinje Neurons of Cerebellar Rats

  • V.V. Grigoriev Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • V.L. Zamoyski Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • E.V. Bovina Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • L.A. Andreeva Institute of Molecular Genetics of the Russian Academy of Sciences, 2, Academician I.G. Kurchatov’s square, Moscow, 123182 Russia
  • N.F. Myasoedov Institute of Molecular Genetics of the Russian Academy of Sciences, 2, Academician I.G. Kurchatov’s square, Moscow, 123182 Russia
Keywords: peptide analogues of Semax, AMPA receptors, Purkinje neurons

Abstract

New peptides analogues of Semax can potentiate AMPA receptors induced currents at lower concentrations (1011–108 M) than those of Semax. This ability suggests that they may have cognitive-stimulating properties.

References

  1. Gold, P. E. Vanbuskirk, R. (1976). Enhancement and Impairment of Memory Processes with Post-Trial Injections of Adrenocorticotropic Hormone. Behavioral Biology, 16(4), p. 387-400. DOI

  2. Ashmarin, I. P., Nezavibatko, V. N., Myasoedov, N. F., Kamensky, A. A., Grivennikov, I. A., Ponomareva-Stepnaya, M. A., Andreeva, L. A., Kaplan, A. Y., Koshelev, V. B., Ryasina, T. V. (1997). Nootropic analogue of adrenocorticotropin 4-10-semax (the experience of design and investigation over 15 years). Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova, 47(2), p. 420-430.

  3. Dolotov, O. V., Seredenina, T. S., Levitskaya, N. G., Kamensky, A. A., Andreeva, L. A., Alfeeva, L. Y., Nagaev, I. Y., Zolotarev, Y. A., A., G. I., Engele, Y., Myasoedov, N. F. (2003). The heptapeptide SEMAX stimulates BDNF expression in different areas of the rat brain in vivo. Doklady Biological Sciences, 391(1-6), p. 291-295. DOI

  4. Grigoriev, V. V., Andreeva, L. A., Zamoyski, V. L., Shevchenko, V. P., Bachurin, S. O., Myasoedov, N. F. (2015). The action of the peptide drug Semax on the currents of AMPA receptors of rat cerebellar Purkinje cells. Doklady Biochemistry and Biophysics, 460(1); p. 47-48. DOI

  5. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., Sigworth, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Archives, 391(2), p. 85-100. DOI

  6. Kaneda, M., Nakamura, H., Akaike, N. (1988). Mechanical and enzymatic isolation of mammalian CNS neurons. Neuroscience Research, 5(4), p. 299-315. DOI

Published
2018-08-22
Section
Experimental Research