SiO₂-Based Aerogels Modified by Covalently Bonded Aromatic Acids as Potential Drug Delivery Systems

  • S.A. Lermontov Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • N.A. Sipyagina Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • A.N. Malkova Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • A.E. Baranchikov Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky av., Moscow, 119991 Russia
  • V.K. Ivanov Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky av., Moscow, 119991 Russia
  • Kh.E. Yorov Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, 31 Leninsky av., Moscow, 119991 Russia
Keywords: aerogels, supercritical drying, surface modification

Abstract

Hybrid aerogels (AGs) containing NH2-group were acylated by benzoic and salicylic acids. The acylated AGs had the specific area value of 170-220m2/g and were not deacylated in H2O-iPrOH mixture at 37°С during 24h. In 0.5% HCl at 37°С hydrolysis takes place releasing free acids and giving the possibility to use aminoaerogels as drug delivery system.

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Published
2018-08-11
Section
Experimental Research