1,5-bis[2-(dioxyphosphoryl)-4-ethylphenoxy]-3-oxapentane and its Analogs as Promising Organic Ligands for Copper(II) Binding

  • V.E. Baulin Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
  • G.S. Tsebrikova Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, 31/4 Leninskii av., Moscow, 119071 Russia
  • D.V. Baulin Frumkin Institute of Physical Chemistry and Electrochemistry, RAS, 31/4 Leninskii av., Moscow, 119071 Russia
  • Y.F. Al Ansary Mari State University, 1 Lenin Square, Republic of Mary El, Yoshkar-Ola, 424000 Russia
Keywords: diphosphonic acids, dissociation constants, copper(II) complexes, stability constants, potentiometry, spectrophotometry

Abstract

The dissociation and complexation ability toward Cu(II) of acidic type phosphoryl-containing podands – tetrabasic 1,5-bis[2-(dioxyphosphoryl)-4-ethylphenoxy]-3-oxapentane (L1), dibasic – 1,5-bis[2-(ethoxyhydroxyphosphoryl)-4-ethylphenoxy]-pentane (L2) and also of their carboxylic analogue dibasic 1,5-bis[2-(oxycarbonylphenoxy)]-3-oxapentane (L3) were investigated by spectrophotometric, conductometric and potentiometric methods in water in the presence 5% of dimethyl formamide. Spectrophotometric and conductometric titration data provided evidence for formation of 1:1 (M:L) complexes. The dissociation constants were determined and species distribution diagrams for studied acids were obtained by potentiometric method. These data are of interest for the design of binary extragents and medicinal drugs based on the studied ligands. The stability constants of Cu(II) 1:1 (M:L) complexes were estimated. Analysis of the titration curves suggests that deprotonation forms of the studied ligands react with Cu2+. Substitution of carboxylic groups in acyclic polyesters by phosphonic results in increased stability of the copper(II) complexes

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Published
2018-09-04
Section
Experimental Research