Biological Activity of Alantolactones in Experiments on Cells

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Published: Oct 2, 2018
DOI: https://doi.org/10.18097/BMCRM00047
Keywords:
alantolactones cytotoxicity cancer cell lines

Main Article Content

S.G. Klochkov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
S.A. Pukhov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
M.E. Neganova
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
E.S. Dubrovskaya
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
L.A. Anikina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
S.V. Afanasyeva
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
A.V. Semakov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia

Abstract

The results of in vitro studies demonstrate cytotoxic activity alantolactone and isoalantolactone, presented in the elecampane plant (Inula helenium) of the natural sesquiterpene lactones. These compounds show toxicity against human cancer cell lines: MS, A549, HCT116, MCF7, RD and K562. The involvement of the p53 signaling pathway in the death of tumor cells, as well as the contribution of reactive oxygen species (ROS) formation during cell death, was studied.

Article Details

How to Cite
Klochkov, S., Pukhov, S., Neganova, M., Dubrovskaya, E., Anikina, L., Afanasyeva, S., & Semakov, A. (2018). Biological Activity of Alantolactones in Experiments on Cells. Biomedical Chemistry: Research and Methods, 1(3), e00047. https://doi.org/10.18097/BMCRM00047
Issue
Vol. 1 No. 3 (2018)
Section
EXPERIMENTAL RESEARCH

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