Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells

  • E.S. Dubrovskaya Institute of Physiologically Active Compounds Russian Academy of Sciences, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
  • A.V. Semakov Institute of Physiologically Active Compounds Russian Academy of Sciences, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
  • S.V. Afanasyeva Institute of Physiologically Active Compounds Russian Academy of Sciences, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
  • M.E. Neganova Institute of Physiologically Active Compounds Russian Academy of Sciences, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
  • V.I. Kozlovski Branch of Talrose Institute for Energy Problems of Chemical Physics of the Russian Academy of Sciences, 1-10 Acad. Semenov prosp., Chernogolovka, 142432 Russia
  • S.G. Klochkov Institute of Physiologically Active Compounds Russian Academy of Sciences, 1 Severny proezd, Chernogolovka, Moscow region, 142432 Russia
Keywords: sesquiterpene lactones, neuroblastoma, peroxide, glutamate, resazurin

Abstract

An the present study we evaluated the effect of natural sesquiterpene lactones of plants of the genus Inula on the cells of neuroblastoma SK-N-MC under conditions of toxic stress induced by H2O2 and glutamate. Lactones increased cell survival under these conditions and the leader compounds were identified in this series. A putative mechanism for the protective action of lactones on cells under condition toxic stress has been proposed.

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Published
2018-07-18
Section
Experimental Research