Biomedical Chemistry: Research and Methods 2024, 7(3), e00235

Multi-directional changes in 8-OHdG concentration in saliva during HER2 EXPRESSION IN breast cancer

E.I. Dyachenko1,2*, E.V. Pahalkova2, E.A. Sarf1, L.V. Bel’skaya1

1Omsk State Pedagogical University, 14 Tukhachevsky emb., Omsk, 644099 Russia; *e-mail: Olseya-120@mail.ru
2Clinical diagnostic laboratory, City Clinical Perinatal Center, Omsk, 644007 Russia

Keywords: saliva; 8-hydroxydeoxyguanosine (8-OHdG); breast cancer; HER2

DOI:10.18097/BMCRM00236

The whole version of this paper is available in Russian.

The purpose of this work was to evaluate changes in the structure of 8-OHdG in saliva in patients with breast cancer depending on molecular biological subtypes. The findings show that decreased salivary 8-OHdG concentrations in the HER2-positive group rapidly correlated with decreased cell differentiation and high Ki-67 levels, reflecting the aggressive nature of the tumor disease and poor survival prognosis. Thus, the presence of high levels of 8-OHdG in the oral cavity may lead to the development of the role of a biological marker of the HER2-positive group with a poor prognosis of breast cancer and can be used as an additional method of diagnosis, patient condition and response to therapy.

Закрыть окно
Table 1. Concentration of 8-OHdG in saliva in different molecular biological subtypes of breast cancer.

Закрыть окно
Table 2. Distribution of 8-OHdG concentration depending on the stage of the disease (St), the level of cell differentiation (G) and the index of proliferative activity Ki-67.

FUNDING

The study was supported by a grant from the Russian Science Foundation, project 23-15-00188.

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