Biomedical Chemistry: Research and Methods 2019, 2(1), e00089

Methods of Delivery of Medications for the Treatment of Oncological Diseases

N.D. Oltarzhevskaja1,2, G.E. Krichevskij2,  M.A. Korovina*1,2, V.I. Shvets3 A.A.Kubatiev4

1LLC «Coletex», 21 Pavlovskaya str., Moscow, 115093, Russia; *e-mail: koletex@list.ru
2LLC «SPO Textilprogress», 21 Pavlovskaya str., Moscow, 115093, Russia
3Lomonosov Moscow State University of Fine Chemical Technologies,
86 Vernadskogo av., Moscow,119571 Russia
4Research Institute of General Pathology and Pathophysiology, 8 Baltijskaya str., Moscow, 125315 Russia

Keywords:direct delivery; sodium alginate; polymer matrix; hydrogel material

DOI:10.18097/BMCRM00089

The whole version of this paper is available in Russian.

The review focuses on the analysis of various methods of obtaining and applying therapeutic materials used for targeted drug delivery to the lesion site of cancer patients. Special attention is paid to creation of targeted drugs by using nanotransporters, obtained by dispersing lipids in water and, in particular, liposomes; efficiencyof such nanotransporters depends the nature of drugs introduced into them (cytostatics). The review also describes methods of targeted transport of cytostatics to tumor tissues. The use of hydrogel therapeutic compositions based on biopolymers polysaccharides for the targeted delivery of chemotherapy drugs introduced into them, allows to control the mass transfer rate of drugs to tumor and to create therapeutic materials with predetermined properties in terms of drug concentration in the lesion site and time prolongation, which reduces toxicity of the treatment and increase its effectiveness.

Figure 1. Mass transfer of 5-fluorouracil from a hydrogel of different composition into the collagen membrane. Red colour shows mass transfer 5-fluorouracil from a hydrogel of sodium alginate into the collagen membrane. Green colour shows mass transfer 5-fluorouracil from a hydrogel of sodium alginate and chitosan succinate (70:30) into the collagen membrane.

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Table 1. The concentration of 5-fluorouracil in tumor tissues, µg/ml.

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