Drug Analysis Methods

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Published: Dec 23, 2019
DOI: https://doi.org/10.18097/BMCRM00110
Keywords:
erythromycin; acetaminophen; ibuprofen; μ diclofenac; medications; electroanalysis

Main Article Content

V.V. Shumyantseva
Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia; Pirogov Russian National Research Medical University, 1 Ostrovitianov str., Moscow 117997, Russia
T.V. Bulko
Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia
P.I. Koroleva
Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia

Abstract

Modern methods of analysis of drugs for their quantitative assessment are considered. Particular attention is paid to the electrochemical methods of drug registration, based on the reaction of electrooxidation of molecules. Systems and materials for modifying electrodes are described, as well as methods for producing modified electrodes for electrochemical reactions on the surface of electrodes. The authors present data on the electroanalysis of acetaminophen, diclofenac, ibuprofen, omeprazole, using electrodes modified with carbon nanomaterials based on carbon nanotubes and graphene. It was shown that electroanalytical methods allow the registration of therapeutic drugs in a wide range of detectable concentrations (0.1 μМ - 10 mM), which can be used to work with biological fluids (plasma, blood, urine), to conduct drug monitoring and study drug-drug interactions.

Article Details

How to Cite
Shumyantseva, V., Bulko, T., & Koroleva, P. (2019). Drug Analysis Methods. Biomedical Chemistry: Research and Methods, 2(4), e00110. https://doi.org/10.18097/BMCRM00110
Issue
Vol. 2 No. 4 (2019)
Section
PROTOCOLS OF EXPERIMENTS, USEFUL MODELS, PROGRAMS AND SERVICES

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