Методы анализа лекарственных препаратов

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Опубликован: Dec 23, 2019
DOI: https://doi.org/10.18097/BMCRM00110
Ключевые слова:
эритромицин; ацетаминофен; ибупрофен; диклофенак; лекарственные препараты; электроанализ

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В.В. Шумянцева
Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, 119121, Москва, ул. Погодинская, 10; Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, 117513, Москва, ул. Островитянова, 1
Т.В. Булко
Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, 119121, Москва, ул. Погодинская, 10
П.И. Королева
Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, 119121, Москва, ул. Погодинская, 10

Аннотация

Рассмотрены современные методы количественного анализа лекарственных препаратов. Особое внимание уделено электрохимическим методам регистрации лекарственных средств, основанным на реакции электроокисления молекул. Описаны системы и материалы для модификации электродов, а также методы получения модифицированных электродов для электрохимических реакций на поверхности электродов. Приведены данные авторов по электроанализу ацетаминофена, диклофенака, ибупрофена, омепразола с помощью электродов, модифицированных углеродными наноматериалами на основе углеродных нанотрубок и графена. Показано, что электроаналитические методы позволяют регистрировать терапевтические препараты в широком диапазоне определяемых концентраций (0.1 мкМ – 10 мМ). Они могут быть использованы для работы с биологическими жидкостями (плазма, кровь, моча), для проведения лекарственного мониторинга и исследования межлекарственных взаимодействий.

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Как цитировать
Шумянцева V., Булко T., & Королева P. (2019). Методы анализа лекарственных препаратов. Biomedical Chemistry: Research and Methods, 2(4), e00110. https://doi.org/10.18097/BMCRM00110
Выпуск
Том 2 № 4 (2019)
Раздел
ПРОТОКОЛЫ ЭКСПЕРИМЕНТОВ, ПОЛЕЗНЫЕ МОДЕЛИ, ПРОГРАММЫ И СЕРВИСЫ

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