Effect of Endogenous Peptides on the Currents of NMDA- and AMPA-Receptors of Neurons of the Cortex, Hippocampus and Cerebellum of Rat Brain

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Published: Oct 1, 2018
DOI: https://doi.org/10.18097/BMCRM00021
Keywords:
NMDA- and AMPA-receptors delta-sleep-inducing peptide (DSIP) corticotropin-like intermediate frontal peptide (CLIP) somatostatin uridine muramyl dipeptides (MDP)

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V.V. Grigoriev
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia
E.V. Bovina
Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 1 Severny proezd, Moscow region, Chernogolovka, 142432 Russia

Abstract

The obtained results show that endogenous peptides play an important role in the regulation of the glutamatergic mediator system of the brain. They act in extremely low concentrations, starting at 1 × 10–14 M, their effects are concentration-dependent and reversible, thus indicating the exclusive specificity of the corresponding receptors. The range of their influence on responses of postsynaptic glutamate receptors is rather narrow and, as a rule, does not exceed 60-70% of control. We have demonstrated for the first time that CLIP blocks NMDA receptors and potentiates AMPA receptors in a wide range of concentrations (6 orders of magnitude); this is very important for manifestation of memory-stimulating effect. Somatostatin blocking NMDA receptors and potentiating AMPA receptors, also plays an important role in the mechanisms of memory formation. Obviously, there is a great similarity in the action of both peptides on AMPA and NMDA receptors. Thus our results provide the first information about regulation of including cognitive processes and memory mechanisms by endogenous compounds. This mechanism particularly involves regulation of AMPA and NMDA receptors in the brain.

Article Details

How to Cite
Grigoriev, V., & Bovina, E. (2018). Effect of Endogenous Peptides on the Currents of NMDA- and AMPA-Receptors of Neurons of the Cortex, Hippocampus and Cerebellum of Rat Brain. Biomedical Chemistry: Research and Methods, 1(3), e00021. https://doi.org/10.18097/BMCRM00021
Issue
Vol. 1 No. 3 (2018)
Section
EXPERIMENTAL RESEARCH

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