Multi-directional Changes in 8-OHdG Concentration in Saliva during HER2 Expression in Breast Cancer

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Published: Oct 1, 2024
DOI: https://doi.org/10.18097/BMCRM00236
Keywords:
saliva; 8-hydroxydeoxyguanosine (8-OHdG); breast cancer; HER2

Main Article Content

E.I. Dyachenko
Omsk State Pedagogical University, 14 Tukhachevsky emb., Omsk, 644099 Russia; Clinical diagnostic laboratory, City Clinical Perinatal Center, Omsk, 644007 Russia
E.V. Pahalkova
Clinical diagnostic laboratory, City Clinical Perinatal Center, Omsk, 644007 Russia
E.A. Sarf
Omsk State Pedagogical University, 14 Tukhachevsky emb., Omsk, 644099 Russia
L.V. Bel`skaya
Omsk State Pedagogical University, 14 Tukhachevsky emb., Omsk, 644099 Russia

Abstract

The purpose of this work was to evaluate changes in the structure of 8-OHdG in saliva in patients with breast cancer depending on molecular biological subtypes. The findings show that decreased salivary 8-OHdG concentrations in the HER2-positive group rapidly correlated with decreased cell differentiation and high Ki-67 levels, reflecting the aggressive nature of the tumor disease and poor survival prognosis. Thus, the presence of high levels of 8-OHdG in the oral cavity may lead to the development of the role of a biological marker of the HER2-positive group with a poor prognosis of breast cancer and can be used as an additional method of diagnosis, patient condition and response to therapy.

Article Details

How to Cite
Dyachenko, E., Pahalkova, E., Sarf, E., & Bel`skaya, L. (2024). Multi-directional Changes in 8-OHdG Concentration in Saliva during HER2 Expression in Breast Cancer. Biomedical Chemistry: Research and Methods, 7(3), e00236. https://doi.org/10.18097/BMCRM00236
Issue
Vol. 7 No. 3 (2024)
Section
CLINICAL STUDIES

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