Blood-Saliva Barrier: Models of its Reproduction

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Published: Mar 23, 2026
DOI: https://doi.org/10.18097/BMCRM00308
Keywords:
blood-salivary barrier; modeling; ex vivo; in vitro; oral mucosa equivalents; in silico

Main Article Content

E.I. Dyachenko
Biochemistry Research Laboratory, Omsk State Pedagogical University, 14, Tukhachevsky embankment str., Omsk, 644099, Russia
L.V. Bel’skaya
Biochemistry Research Laboratory, Omsk State Pedagogical University, 14, Tukhachevsky embankment str., Omsk, 644099, Russia

Abstract

In this review we have summarized existing approaches used to study the blood-saliva barrier in vitro. Investigating the structural and functional characteristics of the blood-saliva barrier in both health and disease requires models that adequately reflect real human physiology. Accordingly, we evaluated currently available research models, such as ex vivo, in vitro (including TR 146, HSY, TEER), oral mucosal equivalents (OME), and in silico systems. To build more accurate in vitro models of the blood-saliva barrier, it is necessary to consider additional parameters. These parameters include the rheological properties of saliva, changes in blood flow and innervation, the state of the immune system, and the oral microbiome. A comprehensive understanding of these components and the characteristics of the blood-saliva barrier is necessary for the development of complex in vitro models.

Article Details

How to Cite
Dyachenko, E., & Bel’skaya, L. (2026). Blood-Saliva Barrier: Models of its Reproduction. Biomedical Chemistry: Research and Methods, 9(1), e00308. https://doi.org/10.18097/BMCRM00308
Issue
Vol. 9 No. 1 (2026): Online first
Section
REVIEWS

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