Гематосаливарный барьер: модели его воспроизведения

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pdf (English)
Опубликован: Mar 23, 2026
DOI: https://doi.org/10.18097/BMCRM00308
Ключевые слова:
гематосаливарный барьер; моделирование; ex vivo; in vitro; эквиваленты слизистой оболочки полости рта; in silico

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Е.И. Дьяченко
Научно-исследовательская лаборатория биохимии, Омский государственный педагогический университет, 644099, Омск, ул. Набережная Тухачевского, 14
Л.В. Бельская
Научно-исследовательская лаборатория биохимии, Омский государственный педагогический университет, 644099, Омск, ул. Набережная Тухачевского, 14

Аннотация

Цель данного исследования — всесторонне описать как хорошо известные, так и совершенно новые подходы к изучению гематосаливарного барьера (ГСБ) in vitro. Исследование структурных и функциональных характеристик ГСБ как в здоровом состоянии, так и при патологии требует моделей, адекватно отражающих реальную физиологию человека. Соответственно, мы оценили доступные в настоящее время исследовательские модели, такие как ex vivo, in vitro (включая TR 146, HSY, TEER), эквиваленты слизистой оболочки полости рта (OME) и системы in silico. Для создания более адекватных моделей ГСБ in vitro необходимо учитывать дополнительные параметры, к которым относятся реологические свойства слюны, изменения кровотока и иннервации, состояние иммунной системы и микробиом полости рта. Всестороннее понимание этих компонентов и характеристик ГСБ необходимо для разработки сложных моделей in vitro.

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Как цитировать
Дьяченко E., & Бельская L. (2026). Гематосаливарный барьер: модели его воспроизведения. Biomedical Chemistry: Research and Methods, 9(1), e00308. https://doi.org/10.18097/BMCRM00308
Выпуск
Том 9 № 1 (2026): Принято в печать
Раздел
ОБЗОРЫ

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