The HYBOT 3D MF Application and it Integration with CoMFA

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V.S. Skvortsov
A.V. Mikurova
O.A. Raevsky


The program “HYBOT 3D MF” based on the potential “6-8” modified by using HYBOT hydrogen bonding factors has been developed. An integration with “QSAR and Advanced CoMFA” module of the SYBYL-X is performed by set of macros written in SPL. A full working version of the program is available at For a number of sets of chemical compounds having pronounced differences in groups with the hydrogen bonding potential, the use of HYBOT 3D MF fields makes it possible to improve the predictive power of models created by the CoMFA technology.

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How to Cite
Skvortsov, V., Mikurova, A., & Raevsky, O. (2018). The HYBOT 3D MF Application and it Integration with CoMFA. Biomedical Chemistry: Research and Methods, 1(3), e00073.


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