New Nitrogen-containing Androstane Derivatives Suppressing Prostate Carcinoma Cells Proliferation

Main Article Content

A.S. Latysheva
A.Yu. Misharin
A.V. Veselovsky
G.E. Morozevich
R.A. Novikov
V.A. Zolottsev

Abstract

Derivatives of 3β-hydroxyandrost-5,16-diene and 3β-hydroxyandrost-5-ene containing 2-oxazoline, 2-benzoxazole, and 2-benzimidazole substituents at C-17 position were synthesized. Docking of the synthesized compounds into the active site of human CYP17A1 predicted their high affinity for the enzyme. Of the 6 new compounds, 5 suppressed the proliferation of prostate carcinoma cells LNCaP and PC-3, and the activity of the oxazoline and benzimidazole derivatives of androsta-5,16-diene significantly exceeded the activity of the known anticancer agents abiraterone and galeterone.

Article Details

How to Cite
Latysheva, A., Misharin, A., Veselovsky, A., Morozevich, G., Novikov, R., & Zolottsev, V. (2024). New Nitrogen-containing Androstane Derivatives Suppressing Prostate Carcinoma Cells Proliferation. Biomedical Chemistry: Research and Methods, 7(3), e00241. https://doi.org/10.18097/BMCRM00241
Section
EXPERIMENTAL RESEARCH

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